Материал: 2016_Kaplan_USMLE_Step_1_Lecture_Notes_Pharmacology
Section VI λ Drugs for Inflammatory and Related Disorders
Glucocorticoids
λ Prednisone, triamcinolone, dexamethasone, hydrocortisone
Drugs Used for Treatment of Gout
λAcute: colchicine, indomethacin
λChronic: allopurinol, probenecid, febuxostat, pegloticase
Drugs Used for Treatment of RA
λNSAIDs
λDMARDs: methotrexate, etanercept, infliximab, anakinra, and others
Drugs Used for Treatment of Asthma
λβ2 agonists: albuterol, terbutaline
λM-blocker: ipratropium, tiotropium
λMethylxanthine: theophylline
λMast-cell stabilizer: cromolyn
λSteroids: flunisolide
λLT modifiers: montelukast, zafirlukast, zileuton
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Chapter 9 λ Inflammatory Disorder Drug List and Practice Questions
1.A patient using NSAIDs for chronic pain develops a bleeding ulcer. What drug is designed to selectively treat ulcers of this type?
A.Famotidine
B.Bismuth
C.Aluminum hydroxide
D.Misoprostol
E.Muscarinic antagonists
2.Acute poisoning with acetaminophen often requires the use of a specific antidote. The beneficial property of this antidote is that it
A.supplies sulfhydryl groups to detoxify a reactive metabolite
B.induces P450 enzymes to enhance elimination
C.blocks the metabolism of acetaminophen
D.enhances renal clearance of acetaminophen
E.chelates acetaminophen
3.Which glucocorticoid is most likely to cause sodium and water retention?
A.dexamethasone
B.betamethasone
C.cortisol
D.celecoxib
E.desmopressin
4.A patient with RA is being treated with ibuprofen, but joint pain and stiffness are increasing. His physician prescribes another drug to be used with ibuprofen that may slow progression of the disease. Unfortunately, side effects develop, including dizziness, tinnitus, blurred vision, and pruritus. Ocular examination reveals corneal deposits and slight retinal pigmentation. What is the drug?
A.Gold salts
B.Etanercept
C.Hydroxychloroquine
D.Methotrexate
E.Thioridazine
5.A patient suffers from troublesome allergic rhinitis due to pollen, and you want to prescribe a drug for her that is least likely to cause sedation. What would your best choice be?
A.Betamethasone
B.Cimetidine
C.Hydroxyzine
D.Loratadine
E.Metoclopramide
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Section VI λ Drugs for Inflammatory and Related Disorders
6.The widely used anticoagulant warfarin is often implicated in drug interactions. If a patient takes warfarin but later begins self-medicating for ulcer pain, what drug useful for ulcers would increase the risk for bleeding?
A.Ranitidine
B.Sucralfate
C.Misoprostol
D.Cimetidine
E.Μetoclopramide
7.A patient with a migraine headache is treated with sumatriptan. This drug is beneficial because it
A.blocks 5HT3 receptors
B.stimulates 5HT1D receptors
C.blocks 5HT4 receptors
D.stimulates 5HT2 receptors
E.blocks muscarinic receptors
8.A child suffering from asthma is to be treated with a drug that blocks the synthesis of leukotrienes. What drug would be an appropriate choice?
A.Cromolyn
B.Montelukast
C.Ipratropium
D.Zileuton
E.Theophylline
9.Which one of the following is likely to be used in motion sickness, and nausea and vomiting of pregnancy?
A.Loratidine
B.Ondansetron
C.Meclizine
D.Fexofenadine
E.Cimetidine
10.For temporary maintenance of a patent ductus arteriosus prior to cardiac surgery in an infant, what is the drug of choice?
A.Alprostadil
B.Indomethacin
C.Epoprostenol
D.Celecoxib
E.Zileuton
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