Материал: 2016_Kaplan_USMLE_Step_1_Lecture_Notes_Pharmacology
Preface
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Kaplan Medical
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SECTION I
General
Principles
Pharmacokinetics 1
Learning Objectives
Answer questions about permeation, absorption, distribution, biotransformation, elimination, and steady state
Solve problems concerning important pharmacokinetics calculations
Pharmacokinetic characteristics of drug molecules concern the processes of absorption, distribution, metabolism, and excretion. The biodisposition of a drug involves its permeation across cellular membrane barriers.
Drug administration (IM, PO, etc.)
Absorption into plasma
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Plasma |
Sites of |
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Distribution to tissues |
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Tissue |
Bound drug |
action |
storage |
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Receptors |
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Free drug |
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Drug metabolism |
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Drug excretion |
(Liver, lung, blood, etc.) |
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(Renal, biliary, |
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exhalation, etc.) |
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Figure I-1-1. Drug Biodisposition |
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