Chapter 3 • Abdomen, Pelvis, and Perineum
POSTERIOR ABDOMINAL BODYWALL
Embryology of Kidneys and Ureter
Renal development is characterized by 3 successive, slightly overlapping kidney systems: pronephros, mesonephros, and metanephros (Figure IIl-3-21).
Stomach
Midgut
Cecum
Pronephros
Mesonephros
Hindgut
Figure 111-3-21 . Pronephros, Mesonephros, and Metanephros
Pronephros
During week 4, segmented nephrotomes appear in the cervical intermediate me soderm ofthe embryo. These structures grow laterally and canalize to form neph ric tubules. The first tubules formed regress before the last ones are formed. By the end ofweek 4, the pronephros disappears and does not function.
Mesonephros
In week 5, the mesonephros appears as S-shaped tubules in the intermediate mesoderm of the thoracic and lumbar regions of the embryo.
•The medial end of each tubule enlarges to form a Bowman's capsule into which a tuft of capillaries, or glomerulus, invaginates.
•The lateral end of each tubule opens into the mesonephric (Wolffian) duct, an intermediate mesoderm derivative. The duct drains into the hindgut.
•Mesonephric tubules function temporarily and degenerate by the begin ning of month 3. The mesonephric duct persists in the male as the ductus epididyrnidis, ductus deferens, and the ejaculatory duct. It disap pears in the female.
Metanephros
During week 5, the metanephros, or permanent kidney, develops from 2 sources: the uretericbud, a diverticulum of the mesonephric duct, and the metanephric mass (blastema), from intermediate mesoderm of the lumbar and sacral regions (Figure IIl-3-22).
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