Материал: part17

YYY.1.2 Example of exogenous substance administration to encode tumor cell line​

Onlytheexogenoussubstanceinformationisincludedinthisexampleandcontentdescribinganimalhandling,anesthesiainformation,​ etc. is excluded for clarity. Indeed, given the optionality of the other content, it would be possible to create an Acquisition Context SR​ instance that describes only the exogenous substance information and nothing else.​

The content tree structure would resemble:​

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YYY.1.3 Informative References​

YYY.1.3.1 Method Descriptions​

[Stout et al 2013] Molecular Imaging. Stout D, Berr SS, LeBlanc A, Kalen JD, Osborne D, Price J, Schiffer W, Kuntner C, and Wall J.​ 2013. 12. 7. 1-15. “Guidance for Methods Descriptions Used in Preclinical Imaging Papers”. http://journals.sagepub.com/​ doi/pdf/10.2310/7290.2013.00055 .​

[David et al 2013a] Comparative Medicine. David JM, Chatziioannou AF, Taschereau R, Wang H, and Stout DB. 2013. 63. 5. 386–91.​ “The Hidden Cost of Housing Practices: Using Noninvasive Imaging to Quantify the Metabolic Demands of Chronic Cold​ Stress of Laboratory Mice”. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796748/ .​

[David et al 2013b] Journal of the American Association for Laboratory Animal Science. David JM, Knowles S, Lamkin DM, and Stout​ DB. 2013. 52. 6. 738–44. “Individually Ventilated Cages Impose Cold Stress on Laboratory Mice: A Source of Systemic Ex-​ perimental Variability”. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838608/ .​

[Rosenbaum et al 2009] Journal of the American Association for Laboratory Animal Science. Rosenbaum MD. 2009. 48. 6. 763–73.​ “EffectsofCage-ChangeFrequencyandBeddingVolumeonMiceandTheirMicroenvironment”. http://www.ncbi.nlm.nih.gov/​ pmc/articles/PMC2786931/ .​

[Fueger et al 2006] Journal of Nuclear Medicine. Fueger BJ. 2006. 47. 6. 999–1006. “Impact of Animal Handling on the Results of​ 18F-FDG PET Studies in Mice”. http://jnm.snmjournals.org/content/47/6/999 .​

[Dandekar et al 2007] Journal of Nuclear Medicine. Dandekar M. 2007. 48. 4. 602–7. “Reproducibility of 18F-FDG microPET Studies​ in Mouse Tumor Xenografts”. 10.2967/jnumed.106.036608. http://jnm.snmjournals.org/content/48/4/602 .​

[Lee et al 2005] Journal of Nuclear Medicine. Lee KH. 2005. 46. 9. 1531–36. “Effects of Anesthetic Agents and Fasting Duration on​ 18F-FDG Biodistribution and Insulin Levels in Tumor-Bearing Mice”. http://jnm.snmjournals.org/content/46/9/1531 .​

[Balcombe et al 2004] Journal of the American Association for Laboratory Animal Science. Balcombe JP. 2004. 43. 6. 42–51.​ “Laboratory Routines Cause Animal Stress”. .​

[Van der Meer et al 2004] Journal of the American Association for Laboratory Animal Science. Van der Meer E. 2004. 38. 4. 376–83.​ “Short-termeffectsofadisturbedlight–darkcycleandenvironmentalenrichmentonaggressionandstress-relatedparameters​ in male mice”. http://www.animalexperiments.info/resources/Studies/Animal-impacts/Stress.-Balcombe-et-al-2004./​ Stress-Balcombe-et-al-2004.pdf .​

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[Tabata et al 1998] Laboratory Animals. Tabata H. 1998. 32. 2. 143–48. “Comparison of Effects of Restraint, Cage Transportation,​ Anaesthesia and Repeated Bleeding on Plasma Glucose Levels between Mice and Rats”. 10.1258/002367798780599983.​ http://lan.sagepub.com/content/32/2/143 .​

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ZZZ Content Assessment (Informative)​

The following use cases exemplify the use of Content Assessment Results IOD.​

ZZZ.1 RT Plan Treatment Assessment Use Case​

ARTPlanSOPInstanceissentfromaTreatmentPlanningSystem(TPS)toaQualityAssurance(QA)ApplicationandtotheTreatment​ Management System (TMS). The TMS de-composes the content for internal storage. At the time of treatment the TMS re-composes​ the Instance and sends it to the operator console of the linear accelerator. However, during re-composition an error occurs and one​ jaw specification is omitted from the recomposed Instance and the Beam Dose in the Fraction Scheme Module is set to 0.0.​

The operator console requests the QA Application to perform an assessment to compare the copy of the Instance received from the​ operator console with the copy of the Instance received earlier from the TPS. The QA Application retrieves the Instance from the op-​ eratorconsole.TheQAApplicationalsoperformsanassessmentbyre-calculationofthedosimetricparametersintheassessedplan.​ Although the Beam Meterset in the assessed plan (from the operator console) is the same as the Beam Meterset in the comparison​ plan(fromtheTPS),theBeamMetersetre-calculatedbytheQAApplicationisdifferentduetothemissingjaw.Furtheronitisdetected,​ that all Beam Dose values have the value 0.0.​

Beam Meterset for the current treatment device in this example is expressed in Monitor Units.​

Table ZZZ.1-1. Content Assessment Results Module Example of a RT Plan Treatment Assessment​

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