Материал: part17

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- Standard -​

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<response status="400 404 406 410 503"></response> </method>

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III Ophthalmic Thickness Map Use Cases​ (Informative)​

III.1 Introduction​

Several ophthalmic devices produce thickness and/or height measurements of certain anatomical features of the posterior eye (e.g.,​ opticnerveheadtopography,retinalthicknessmap,etc.).Themeasurementsaremappedtopographicallyasmonochromaticimages​ with pseudo color maps, and used extensively for diagnostic purposes by clinicians.​

III.2 Macular Retinal Thickness Example​

Quantitative ophthalmic OCT image analysis provides essential thickness measurement data of the retina. In the clinical practice two​ thicknessparametersarecommonlyused:totalretinalthickness(TR)inmacularregionandretinalnervefiberlayerthickness(RNFL)​ in optic nerve head (ONH) region. TR is widely applied to assess various retinal pathologies involving macula (e.g., cystoid macular​ edema, age-related macular degeneration, macular hole, etc.). The RNFL thickness measurement is most commonly used for​ glaucoma assessment.​

Figure III.2-1 is an example of 2D TR map computed on a 3D OCT cube data from a healthy eye. The color bar on the left provides​ a color-to-thickness representation to allow interpretation of the false color coded 2D thickness map in the middle. The image on the​ right shows one OCT frame representing a retinal cross section along the red line (across the middle of the thickness map). TR is​ defined as the thickness between internal limiting membrane (white line on the OCT frame on the right) and RPE/Choroid interface​ (blue line on the OCT frame). These two borders are automatically detected using a segmentation algorithm applied to the entire 3D​ volume.​

Figure III.2-1. Macular Example Mapping​

III.3 RNFL Example​

Figure III.3-1 is an example of a 2D RNFL map computed on a 3D OCT cube data from a healthy eye. The figure layout is the same​ as the previous example. The RNFL thickness is limited to the thickness of this single layer of the retina that is comprised of the​ ganglion cell axons that course to the optic nerve head and exit the eye as the optic nerve. Note that this image depicts a BMP mask​ in the center of the map where the optic nerve head (ONH) exists and no RNFL measurements can be obtained. In this example, the​ mask is displayed as a black area, which does not contain any thickness information (not zero micron thickness). Since the color bar​ representation is not relevant at the ONH, common practice is to mask it to avoid confusion or misinterpretation due to meaningless​ thickness data in this area.​

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