Материал: Oxford American Handbook of Urology ( PDFDrive )

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Disorders of erectile function, ejaculation, and seminal vesicles

Physiology of erection and ejaculation 484

Impotence: evaluation 488

Impotence: treatment 490

Retrograde ejaculation 492

Peyronie’s disease 494

Priapism 496

484 CHAPTER 12 Erectile function and ejaculation

Physiology of erection and ejaculation

Innervation

Autonomic

Autonomic sympathetic nerves originating from T11–L2, and parasympathetic nerves originating from S2–4 join to form the pelvic plexus. The cavernosal nerves are branches of pelvic plexus (i.e., parasympathetic) that innervate the penis.

Parasympathetic stimulation causes erection; sympathetic activity causes ejaculation and detumescence (loss of erection).

Somatic

Somatosensory (afferent) information travels via the dorsal penile and pudendal nerves and enters the spinal cord at S2–4. Onuf nucleus (segments S2–4) is the somatic center for efferent (i.e., somatomotor) innervation of the ischiocavernosus and bulbocavernosus muscles of the penis.

Central

The medial preoptic area (MPOA) and paraventricular nucleus (PVN) in the hypothalamus are important centers for sexual function and penile erection.

Mechanism of erection

Neuroendocrine signals from the brain, created by audiovisual or tactile stimuli, activate the autonomic nuclei of the spinal erection center (T11–L2 and S2–4). Signals are relayed via the cavernosal nerve to the erectile tissue of the corpora cavernosa, where nitric oxide (the principle neurotransmitter for penile erection) is released from nonadrenergic, noncholinergic (NANC) nerve terminals and from endothelium in the penis.

Cyclic GMP is then secondarily released via guanlyl cyclase, lowering intracellular calcium concentration within the endothelial cells, causing smooth muscle relaxation and increased arterial blood flow into the cavernosal sinuses of the penis.

A veno-occlusive mechanism (Table 12.1) is created by expansion of the sinusoidal spaces against the tunica albuginea, which compresses the subtunical venous plexuses, decreasing venous outflow and thus allowing “trapping” of blood within the erect penis. Maximal stretching of the tunica albuginea acts to compress the emissary veins that lie within its inner circular and outer longitudinal layers, reducing venous flow even further. Rising intracavernosal pressure and contraction of the ischiocavernosus muscles produces a rigid erection.

Following orgasm and ejaculation, vasoconstriction due to increased sympathetic activity and breakdown of cGMP via phophodiesterase type 5 produces detumescence (Figs. 12.1 and 12.2).

Ejaculation

Tactile stimulation of the penis causes sensory information to travel (via the pudendal nerve) to the lumbar spinal sympathetic nuclei. Sympathetic efferent signals (traveling in the hypogastric nerve) cause contraction of smooth muscle of the epididymis, vas deferens, and secretory glands, propelling spermatozoa and glandular secretions into the prostatic urethra.